Newsletter | January 19, 2026

01.19.26 -- Moving Leukopaks From GTP To GMP Is One Cell Therapy Trend To Watch In '26

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Resilience is vital in biomanufacturing as global economic shifts threaten operations. Join Bioprocess Online editor Tyler Menichiello for a panel on navigating tight funding, shortages, and market pressures, featuring leaders from Sanofi, Vaxart, and industry veteran James Sapirstein amid inflation, costs, and supply chain disruption. Learn More!

FOCUS ON UPSTREAM MANUFACTURING

Moving Leukopaks From GTP To GMP: A Cell Therapy Trend To Watch In '26

Cell therapy stumbled in 2025. Solving the variability in starting material quality is critical to stabilizing manufacturing in 2026.

Metabolic Pathways And The Immune System

Metabolic pathways define immune cell roles, from glycolysis fueling inflammation to fatty acid oxidation sustaining memory and tolerance. Discover how energy metabolism shapes immune responses.

Advanced Approaches For Developing And Optimizing Perfusion Platforms

Explore how to effectively use small-scale perfusion-mimic systems to identify optimal cell culture media and significantly increase volumetric productivity for large-scale biomanufacturing.

The Proven, Practical Gateway To Upstream Process Intensification

N-1 perfusion enables higher inoculum densities, faster production, and reduced costs without altering fed-batch processes. Uncover a practical path to intensification for biologics manufacturers.

Optimizing CAR T-Cell Development Starts With Your Cell Incubator

Learn how precise cell culture conditions are critical to advancing CAR T-cell therapies, which empowers researchers to develop more effective cancer treatments and accelerate breakthroughs.

Media Exchange In iPSC Cell Expansion And Differentiation

Low-shear, closed-system media exchange in iPSC is vital for scalability. Compare automated centrifugation to gravity sedimentation, showing equivalent or superior differentiation outcomes.

The Impact Of Flexibility On HEK293 Cell Growth And Viability

Achieving high viable cell densities in HEK293 cultures is crucial. Examine how precise environmental adjustments support robust growth for gene therapy applications.

Simplify Cell Line Development

A streamlined workflow combining microfluidic dispensing and multimodal imaging enables efficient single-cell isolation, viability assessment, and outgrowth analysis to support cell line development.

Comparing Advanced Cell Culture Vessels Vs. Traditional Options

Find out how innovative cell culture vessel design enables high-density cell growth with superior gas exchange and a closed system to scale up bioproduction efficiently while maintaining consistency.

Addressing Complex Challenges And Developing Innovative Solutions

Gain insight into two projects that focus on improving efficiency and productivity in biopharmaceutical manufacturing while reducing the cost of goods through process intensification.

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Webinar - Next-level cell lines: An integrated approach to biologic innovation

As AI and digital tools rapidly evolve, they are poised to reshape biopharmaceutical cell line development and subsequent manufacturing, overcoming inefficiencies in expression, scalability, and production. Join us to learn how a cell culture media platform and state-of-the-art biologics expression system routinely deliver high-titer clones (8–11 g/L) in 14 weeks for monoclonal and multispecific antibodies.

UPSTREAM MANUFACTURING SOLUTIONS

Scale AAV Production Utilizing The Only Transfection Complex Stabilizer - Mirus Bio

Powering Production Of Viral Vector-Based Therapies - Cytiva

Enhance Post-EP Proliferation - Femtobiomed Inc.

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