Minimizing Fluid Loss By Monitoring Back Pressure During Clarification

This case study highlights how incorporating back pressure monitoring in peristaltic pumping in biologics manufacturing can significantly reduce fluid loss and process risk. A biopharma CDMO experienced a costly rupture during lentiviral vector clarification, which was traced to elevated back pressure caused by filter fouling. By implementing Masterflex^® MasterSense^® peristaltic pumps with integrated single-use pressure sensors, the organization improved process control and mitigated the risk of future pressure-related incidents with minimal operational disruption.