Measure And Control In-Line Protein Concentration With KrosFlo® RS 30 And CTech™ FlowVPX® System

The KrosFlo® RS 30 is a fully automated tangential flow filtration (TFF) system engineered for use in cGMP environments, specifically for the concentration and diafiltration of biologically derived proteins and antibodies in clinical and commercial production. Designed to streamline final product concentration and buffer exchange procedures, the RS 30 enables automated transitions between processes based on real-time in-process metrics. Traditional TFF systems often rely on volume concentration factor (VCF) calculations to estimate product concentration, which can introduce errors and lead to deviations from target values. To address this challenge, the RS 30 integrates the CTech FlowVPX® spectrophotometer, featuring variable pathlength technology, for real-time, in-line concentration measurement within the TFF recirculation loop. This innovation allows for automatic process transitions based on actual concentration values rather than estimates, which enhances accuracy and reliability.

Discover how the KrosFlo RS 30 and CTech FlowVPX can elevate your bioprocessing workflows.