Maximizing Scale Up: Critical Considerations For Buffer Preparation

By William Whitford, Strategic Solutions Leader Arcadis DPS Group

Buffers are applied throughout the processing train, including biological sample reception, upstream and downstream processing, resins storage, and as excipients in drug product. For several reasons over the past few years the complexity and critical nature of buffer preparations has grown, demanding that biomanufacturers consider several essential factors throughout their processes.

Factors to consider involve the buffer type, volumes, and timing required– as well as a manufacturer’s finances, facility, and personnel available. Go into further detail with this document to learn about the steps of buffer development, choosing a supply approach and strategy, choosing between in-house and outsourcing buffer activities, and more.

Originally published by Questex Content Marketing