3M™ Polisher ST Replacing Chromatography Column At Scale

Biopharmaceutical companies are approaching the limits of manufacturing productivity and scalability, and innovative downstream bioprocessing (DSP) solutions are required to address these challenging issues. The bottleneck in process-scale chromatography negates any advantages of scaling up earlier process units, since bind-and-elute chromatography steps are driven by mass rather than volume.

This means that savings made upstream do not translate into increased productivity during purification. Larger columns also impact directly on facility layouts, costs and infrastructure because the space and buffer volumes for all steps also increase. As a consequence, pool and buffer volumes act as serious limitations when it comes to the introduction of high-titer processes into existing facilities.

We explore the 3M™ Polisher ST which offers not only economic benefits and versatility, but it also has specific functional advantages over equivalent packed-bed columns.