3M™ Polisher ST Datasheet

3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein (HCP) impurities, viruses, and other negatively charged contaminants in flow-through polishing chromatography of biopharmaceutical process streams. 3M Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium (Gu) functional membrane.

The upstream Q-functional nonwoven provides reduction of turbidity (when present), DNA, and endotoxin, as well as a portion of the product’s AEX capacity for HCP and virus reduction. The downstream guanidinium functional membrane layers of 3M Polisher ST are salt tolerant and provide high HCP and virus reduction performance in a wider range of conditions compared to conventional Q-functional AEX resins.

Learn more about the 3M Polisher ST can improve monoclonal antibody (mAb) development and manufacturing processes in traditional polishing process conditions.