Intensification Of Upstream Operations With Dynamic Perfusion

Fed-batch cultivation remains the standard for monoclonal antibody production, but perfusion offers compelling opportunities to improve product quality, yield, and facility utilization. Its broader adoption, however, has been limited by process complexity and the challenges of maintaining aseptic operations over extended periods. Dynamic perfusion provides a more streamlined path to continuous cell culture by using a fixed volumetric media feed rate to guide cell growth and metabolism over time. This approach eliminates the need for cell bleed and daily adjustments to the perfusion rate, reducing operational demands while retaining the benefits of process intensification.

Explore how dynamic perfusion compares with other upstream strategies in productivity, media consumption, and space-time yield, and learn how it can help address common barriers to continuous biomanufacturing.