Inline Buffer Dilution System
Designed to streamline buffer delivery in downstream applications
Buffers and salts are typically the largest constituents by volume used in biopharmaceutical downstream processing steps for manufacturing most products. The variety of buffer solutions used across a manufacturing facility requires flexible, cost-efficient infrastructure and on-time delivery to meet process demand.
Avantor is ready to help you simplify your buffer delivery for ultrafiltration/diafiltration (UF/DF) as part of your mAbs downstream processing with our capabilities and systems for inline buffer dilution.
Concentrated buffer delivery can reduce labor costs and facility footprint by eliminating the need for large holding vessels for buffer prep. Using an inline static mixer, accurate mixing is achieved with pH and conductivity inline measurements with discharge features to remove out of specification material. Controlled feed rates match process needs with two available dilution control methods for flow rate or conductivity.
With experience in both chemicals manufacturing and single-use system design, Avantor can work with you to design custom concentrated solutions or proprietary solutions in 10 L single-use bags ready for inline dilution to de-bottleneck your downstream processes.
- Batch programmable for lot-to-lot consistency
- All fluid pathways are single-use, ready to use upon delivery
- 50L mixing vessel
- Ideal for common buffers and reagents including PBS – Phosphate Buffer Saline, Tris-HCL and NaOH
- Work with our specialized team to develop proprietary solutions