Improved Clearance Of Host Cell Proteins After Virus Inactivation

Post-viral inactivation filtration can do more than remove precipitates. When carefully developed, it may also reduce residual host cell proteins before polishing chromatography, including lipases that can compromise monoclonal antibody stability. Selecting the right filtration approach requires a close look at several competing priorities: impurity clearance, process fluid throughput, and overall cost.

See how multiple Seitz filter media with different charge characteristics and an anion exchange membrane were evaluated using two distinct feeds. The findings illustrate how feed properties and media selection can influence filtration performance and help shape a more reliable, scalable purification process.