Video

HyPerforma 5:1 Single-Use Bioreactor Overview Video

Source: Thermo Fisher Scientific

The Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) is one of the most widely used S.U.B.s designed for mammalian cell culture. We first launched the S.U.B. in 2006 and updated its design in 2013, while maintaining its robust, top-down, stirred-tank mixing system. The S.U.B. has been widely adopted in process development and clinical trials as well as in bioproduction of cGMP cell culture. As a superior solution, our bioreactors can be easily integrated with any controller available in the market today.

Functional and scalable
The HyPerforma S.U.B. equipment and BPC system are designed using traditional stainless steel bioreactor principles to help ensure optimal cell culture performance. The complete line of HyPerforma S.U.B.s includes 50, 100, 250, 500, 1,000, and 2,000 L sizes with a 5:1 turndown ratio for consistent scalability for final production. We will build what you need, while maintaining our quality and delivery times. Through our open-architecture approach, we have developed a variety of single-use sensors, tubing, and connectors for customer design flexibility.

  • Streamlining of bioprocesses by reducing seed-vessel requirements and maximizing process-vessel usage
  • Seed vessels run at 20% volume; fill to larger volume (>40%) after 1–2 days
  • Reduces hardware and single-use bag requirements
  • Reduces cell transfers and associated adaptation
  • 5:1 turndown ratio to run the 50 L bioreactor in as low as 10 L working volume or a 2,000 L bioreactor in as low as 400 L working volume