How To Build An Effective Protein Degrader

As a PROTAC scientist, you're tackling tough targets to address diseases like cancer and neurodegenerative conditions. However, PROTAC development comes with challenges like poor cellular permeability and complex characterization.

To build an effective protein degrader, focus on understanding the structure-activity relationship throughout the degradation pathway. This eBook explores four key questions to ensure your PROTAC development is on the right track:

• Is my PROTAC cell-permeable?
• Does my PROTAC form a ternary complex?
• Does my target become ubiquitinated?
• Does ubiquitination drive protein degradation?

Download the full eBook to learn how addressing these questions can streamline your PROTAC development journey.