In many laboratories, the need to consistently generate high-quality data means that managers, scientists, and technicians must ensure their instruments are performing optimally around the clock. Filtering samples before injection into a chromatography instrument is one of the primary ways that technicians can protect their column and instrument from unnecessary wear and excess downtime.
Filtration of both the sample and mobile phase prior to analysis helps increase the lifespan of chromatography columns, reducing instrument performance and removing any particles that may interfere with the chromatogram. Sample filtration is most often conducted using syringe filters for their time-effective and easy-to-implement method.
In this article we review how particulate removal through filtration effects column life and how to handle difficult to filter samples.