How STUDIUS™ Is Changing Cell Line Development

One project, 7 analytical instruments, 7 staff members, 5 data formats. 3 different permutations of plate names 3 months, 13 excel files, containing 46 sheet worth of data. Manual Vlookups. Copy-and-pastes. USB Sticks. This situation is not uncommon.

Operating within the structure of Chemical, Manufacturing and Control (CMC), Cell Line Development (CLD) is a pivotal control strategy within the development of therapeutic antibodies. Risk-based strategies towards quality control are deeply embedded in CLD yet challenged, as are CLD scientists, on a daily basis with the burden and worry of data consolidation.

Methodologies, utilized in CLD, include viable cell counting, confluency measurements, single cell seeding, plate transfer and consolidation, titer assays and microscopy. It is central to this narrative that data from all these aspects are joined together in a single story of a cell’s journey through this process.