FEATURED ARTICLES

• Osmolality: A Powerful Tool In Bioprocessing

  Learn more about the broad range of applications for osmolality testing and why it is crucial for process development, analytical development, and GMP testing.

• Produce A Monoclonal Cell Line Expressing A Clinical Candidate Bi-Specific Antibody In Less Time

  Explore how implementing a platform that helped a biopharmaceutical company save 6-8 weeks of work whilst still meeting the regulatory requirements. 

• A Simple Solution Slashes Cell Line Development At A Biotech Company

  A biotech company's cell line development team decided to optimize their processes and look for new equipment that could isolate single cells and speed up development. 

• Successfully Filing An IND Using Single Cell Cloning System

  Dr. Andy Tsun, co-founder and VP of Discovery Biology at Biotheus Inc, shares his company's experience using an accelerated workflow for single-cell cloning including how it helped them obtain an IND. 

• Doubling The Speed Of Cell Line Development In A Large Pharmaceutical Company

  We explore how the Cell Line Development group at Janssen R&D was able to reduce one of their development processes to a single step thanks to new technology. 

• FACS Bulk Enrichment In Combination With Cell Cloning Systems Delivers Significant Savings For A CDMO

  Learn how the Cell Line Development (CLD) department at Celonic Ag was able to optimize their workflow with new technology geared towards shortening time lines and lightening workload. 

   

• Reliable Osmolality Testing Of High Concentration mAb Formulations

  Osmolality testing has several bioprocessing applications, and new use cases are constantly emerging. This paper evaluates two osmometers for measuring concentrated protein formulations. 

• Improving Titer, Quality, And Efficiency Of AAV Manufacturing

  This study provides preliminary evidence for impact on overall yield, and quality of the AAV due to a timed osmolality shift with and without a feeding step.

• Improving Cell Line Development Processes Through Accurate, Low Volume And Rapid Automated Cell Counting And Viability

  We will outline the importance of accuracy and efficiency when cell counting and outline how the Viability assay on the ICON can enhance your current processes.

• Enhance Your Cell Line Development Process To Provide Consistent Data Driven Accelerated Workflows

  We outline how the range of technologies support single-cell seeding, image based clonality assurance and allow for informed analysis of critical, cell quality attributes.

• How STUDIUS™ Is Changing Cell Line Development

  Methodologies, utilized in CLD, include viable cell counting, confluency, single cell seeding, plate transfer and consolidation, titer assays and microscopy. It is central to this narrative that data from all these aspects are joined together in a single story of a cell’s journey through this process.

• Clonality In Stem Cell Derived Therapies, A Journey From Process Development To Manufacturing

  Emergent cell therapy companies have an eye on the future production of clinical treatments. Whatever the timescale, the question of when and how to implement practices that will be scalable to cGMP (current Good Manufacturing Practice) often arise.

• Development Of A Highly Efficient, Documented Workflow For Making Clonal Cell Banks Of Gene-Edited iPSCs

  Cell therapy companies need to adopt robust workflows that are designed to best manage consistency, quality of product and meet with appropriate regulatory requirements and manufacturing best practices. We explore the effectiveness of the VIPS + MatriClone workflow for gene-edited hiPSC cells.

• High Efficiency Single Cell Cloning Of hiPSCs While Ensuring Maintenance Of Phenotype

  Reduce time and cost while most importantly maintaining the cell phenotype and genomic integrity as well as providing documented evidence of cell line clonality with viable, high efficiency single cell cloning of hiPSCs.

• High Efficiency Single Cell Cloning Of iPSCs Using Combination Of MatriClone And VIPS

  Review an effective turnkey solution for generating significantly more viable iPSC clones per plate along with image documentation for their clonal derivation.

• Improved Outgrowth For HEK 293 Cell Line Development

  Review clonality and improved outgrowth for HEK 293 cells when developing stable producer cell lines for viral vector production in gene therapy.

• Single Cell Seeding Conditions For Improved Colony Outgrowth

  Cloning efficiency is often overlooked in the cell line development workflow relative to the single cell isolation step. However, recovery and growth of the single cells is a challenging step in the process.

• Keep Integration Of Clonal Workflow Technology Easy For Busy Laboratories

  When it comes to expanding your lab’s capacity, updating existing methods or even starting from scratch you need new technology integration to be simple, quick and professional.

• Combining VIPS And ATUM To Accelerate Cell Line Manufacturing

  Scientists are constantly striving to develop the highest producing clones and to do it faster. We now demonstrate how this can be achieved by using only a handful of cloning plates.

• Osmolality Testing Of Viscous Formulations Using Freezing Point Depression

  Here we detail the osmolality testing of various formulations containing sodium hyaluronate, with a range of viscosities, including semi-solid gels.