How Stability Characterization Parameters Help Create Biologics Developability Profiles

Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a decision on which candidates are worth further development. There are many biophysical characteristics to evaluate when it comes to complex, protein-based therapeutics like biologics. Anyone working to characterize biologics will have different attributes they prioritize or different parameters they aim to optimize – there’s no singular approach.

However, there are commonalities in approaches to de-risking the downstream development of a biologic therapeutic. Broadly, early development researchers are concerned with the structure, stability, and functionality of their biologics candidates. Read this blog to learn about biologics critical attributes evaluated during development and common approaches for their measurement.