Article | April 22, 2026

How Many Of These 7 ADC Handling Considerations Do Have On Your Radar?

SUS - cytotoxicity

ADC manufacturing has entered a new era of complexity, and the handling protocols that once worked well enough are beginning to show their limits. As payloads grow more potent and timelines grow shorter, two risks that rarely get equal attention, operator safety and product degradation, are converging on the same process steps. Cytotoxic exposure during routine liquid handling, mechanical stress on single-use containers during cold chain transport, and light-induced payload degradation are not edge cases. They are predictable challenges that demand deliberate design choices.

This article maps seven handling considerations that are reshaping how ADC manufacturing teams approach fluid management, from closed system architecture and container closure integrity to photostability protection during visual inspection. If your current handling workflow was built before ADCs became a primary focus, some of what follows may prompt a closer look at where the gaps are. Read the full article to find out.

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