Host Cell Protein Removal By Seitz™ PDC3 Depth Filter After Virus Inactivation In mAb Processing

Host cell proteins remain one of the most persistent challenges in biopharmaceutical purification, with the potential to compromise product quality, safety, and overall performance. Removing these impurities often requires multiple steps, including clarification of post–virus inactivation solutions where pH-induced precipitation is common. While filtration is traditionally used to clear these precipitates before polishing chromatography, incorporating a charged depth filter introduces an opportunity to improve HCP reduction earlier in the workflow. Explore how a dual‑layer Seitz™ PDC3 depth filter, built from two stages of Seitz Supra EK1P media, can streamline clarification while removing more than 90% of host cell proteins.

Gain insight into how strategic filter selection enhances impurity control and strengthens downstream purification efficiency.