White Paper

Freezing And Thawing Of Protein Solution

cold thermometer cold chain temperature controll

During the last decades, biotechnology concerning protein drugs developed at an accelerated speed. New biotechnology solutions offer to produce protein drugs at a higher capacity than in the past in order to satisfy the increasing demand. However, the biotechnological production of protein drugs is still a cost-intensive process. By linking production steps with different capacities, the overall manufacturing process can be handled cost-effectively. For instance, large and capital-intensive facilities like fermenters will be used for different products. Usually, the high-purity bulk protein solution is produced as per demand and independent of time from the final protein drug. Sometimes, the various steps are executed at different locations. On the one hand this segregation allows for a conversion of bulk solution according to market demand while on the other hand this segregation leads to storage as well as transportation requirements for the bulk solution.

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