Newsletter | October 20, 2025

10.20.25 -- Fermentation Of Live Biotherapeutic Products In cGMP Environments

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Minimize Contamination with Low and Ultralow Particulate Nalgene Bottles

In controlled environments, even trace particulates can compromise product quality. Thermo Scientific™ Nalgene low and ultralow particulate bottles and carboys deliver sterile, leakproof performance for critical transfer and storage applications. Designed to align with cGMP and regulatory expectations, these solutions help reduce risk, support batch reproducibility, and ensure workflow consistency. See how Nalgene low and ultralow particulate solutions can support your compliance strategy. Read the article.

FOCUS ON UPSTREAM MANUFACTURING

Fermentation Of Live Biotherapeutic Products In cGMP Environments

We follow the journey from master cell bank to large-scale anaerobic fermentation, highlighting the unique needs for working with oxygen-sensitive, strictly anaerobic therapeutic microbes in a cGMP setting. 

Simplify Cell Line Development

Explore a streamlined method for isolating viable single cells using microfluidic dispensing and whole-well imaging that is designed to improve clonality, cell health, and reproducibility.

Unlock Viral Vector Yield And Efficiency With Upstream Intensification

Streamline viral vector manufacturing with perfusion technologies that reduce costs and improve scalability. Discover how a tangential flow depth filtration system enhances yield and quality.

The Hidden Cost Of Off-The-Shelf Media In Cell Therapy

Generic, off-the-shelf media can introduce hidden costs and delays in development. A strategic media approach is a critical advantage that can accelerate your path to the clinic.

Mixing Of Various Dry Powdered Media And Buffers

Learn how this mixing system efficiently handles various powdered media and buffers, ensuring precise solubilization and mixing in applications like cell culture and protein purification.

Overcoming Scale-Up Challenges In iPSC Production: A Joint Investigation

Discover how new processing methods tackle challenges in large-scale stem cell production and how automated, low-shear processing maintains cell health and pluripotency across production scales.

Find The Perfect Balance Between Yield And Desired Glycosylation

Achieving desired glycosylation for therapeutic proteins can be difficult. Explore innovative approaches to optimize this critical quality attribute.

Why Cell Washing Is The Hidden Bottleneck In Gene-Edited Cell Therapy

Scaling up life-saving gene-edited cell therapies means tackling production inefficiencies. Overcoming the time-consuming and risky cell washing step is crucial for clinical and commercial success.

Studying Liposomes In The Nano DSC

Explore how the Nano DSC effectively studies liposomes, revealing thermodynamic properties like Tm and phase transitions, aiding drug delivery advancements.

Optimizing VLP Manufacturing For Gene Editing With Flow Electroporation

Learn how a novel approach to VLP manufacturing can overcome common scalability and consistency issues, enabling high yields and potent gene editing in a single day.

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Webinar: Smart Media Screening & Design: Saving Time and Boosting Titers

Choosing the right culture medium is crucial after cell line development but can be challenging. Join this webinar to explore case studies, high-throughput screening, and strategies for selecting or designing optimal media and feed formulations—helping you save time, improve performance, and accelerate development. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

A Single-Use, Automated Depth Filtration System - Cytiva

CellShot PFEP™ + Proliva™: Enhancing Post-EP Proliferation - Femtobiomed Inc.

Zero Time to Master: PharmaLok ZerO - Nordson MEDICAL

Achieve A New Level Of Viral Vector Productivity - FUJIFILM Biosciences

J.T.Baker® Viral Inactivation Solution - Avantor

On-Line Glucose And Lactate Analyzer - Repligen – PAT

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Webinar: Boosting Vaccine Yields Through Smarter Cell Culture Media Optimization

Optimizing cell culture media is key to efficient, reliable vaccine production. This Thermo Fisher webinar explores how peptones enhance cell growth, viability, and productivity across HEK293 and BHK-21 cell lines. Through case studies and data insights, attendees will learn strategies for integrating peptones to boost yields, streamline workflows, and ensure consistent, high-performance vaccine manufacturing. Click here to learn more.

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