05.11.26 -- Feed Media Can Significantly Impact Process Performance

Uncover how tighter alignment between vector construction and cell banking improved development efficiency, strengthened risk management, and enhanced early-stage program outcomes.

Learn a strategy for scalable bioprocessing and media optimization that drives intensified viral vector production. Achieve high cell density, excellent viability, and consistent AAV titers from 50mL to 5L.

To support a seamless transition from early clinical studies through to commercial manufacturing, cell line expression systems must be carefully designed and selected based on several critical attributes.

Discover how diagnosing ribosome pausing sites and optimizing codon usage dramatically improves bispecific antibody titers, turning difficult-to-express candidates into viable therapeutics.

In Vitro Glycoengineering (IVGE) precisely controls glycosylation to optimize biopharma workflows, serving as a critical platform for advancing key therapeutic areas in today's industry.

N-1 perfusion enables higher inoculum densities, faster production, and reduced costs without altering fed-batch processes. Explore a practical path to intensification for biologics manufacturers.

Low-shear, closed-system media exchange in iPSC differentiation is vital for scalability. This study compares automated centrifugation to gravity sedimentation, showing equivalent or superior outcomes.

Gain insight into designing large Design-of-Experiment (DOE) upstream process development studies and the elements that could positively or negatively affect your throughput.

The circular bioeconomy requires bioprocess scale-up capabilities. Access to flexible, user-friendly pilot-scale equipment is vital for companies to move from lab-bench innovation to commercial reality.

Examine data from an anti-GPCR VHH program that shows how ncAA conjugation barriers, like yield loss, toxicity, incomplete incorporation, can be overcome at scale.

See how stirred-tank bioreactors overcome the scalability limitations of static culture for MSC-EV production, while Raman spectroscopy provides unprecedented real-time quality monitoring.

Electroporation enables genetic research by introducing material into cells, advancing disease modeling, gene therapy, and ion channel studies.