Unlocking The Potential Of Electroporation For Studying Ion Channel-Related Disorders And iPSCs

Genetic disorders such as cystic fibrosis and long QT syndrome often result from mutations in ion channel and transporter genes. In this GEN webinar, Dr. Alfred George discusses an electroporation approach that his group used to create assay-ready cells expressing human ion channel variants suitable for high throughput automated patch clamp recording. The MaxCyte STx enabled functional evaluation of ion channel variants without requiring stable cell line creation.

He highlights MaxCyte electroporation technology, which enables the expression of human ion channel variants in mammalian cells. This technique streamlines high-throughput automated patch clamp recording, allowing functional analysis of ion channel variants without requiring stable cell line development.

Discover how electroporation can introduce or correct mutations in induced pluripotent stem cells (iPSCs), providing a versatile tool for modeling genetic diseases and advancing gene therapy proof-of-concept studies.