Case Study

FACS Bulk Enrichment In Combination With Cell Cloning Systems Delivers Significant Savings For A CDMO

FACS Bulk Enrichment In Combination With Cell Cloning Systems Delivers Significant Savings For A CDMO
The Celonic CLD team with their VIPS instrument. From left to right: Laura Benoit, CLD Scientist; Sébastien Lalevée, CLD Team Manager; Camille Evenou, CLD Scientist; Benjamin Renner, CLD Scientist; Camille Mathieu, DSP Process Engineer.

Celonic AG is a European-based CDMO specializing in biologics manufacturing from mammalian cell lines. Their Cell Line Development (CLD) department is routinely commissioned by customers to generate stable cell lines producing a wide range of proteins, from mAbs to bispecifics and difficult-to-express fusion proteins. This process could take around 29 weeks from receipt of the sequence to fed-batch screening for lead clone selection, and involved up to 500 96-well plates. This was logistically challenging for CLD personnel to handle, so substantially reducing these parameters while maintaining process quality became a primary objective of the department.

 To reach this objective, the department acquired the VIPS™ and Cell Metric®. These two implementations had a dramatic impact -- the gentle, low pressure fluidics of the VIPS proved its worth very quickly for the group. The successful implementation of the VIPS and Cell Metric combination at Celonic has allowed them to quickly and consistently deliver high producing cell lines to their clients with the most complete documentation for a clonally-derived MCB population, as required by the regulatory bodies. Because of these improvements, Celonic has been able to scale out and undertake more client projects in the same timeframe without compromising the quality.

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