Evolving Methods Of Bulk Freezing

For decades, the biopharmaceutical industry relied on rigid stainless-steel cryovessels to manage bulk drug substances. While historically significant, these open systems often struggle with long freezing cycles—sometimes lasting days—and lack the precision required for modern biologics. The shift toward single-use technology marks a critical turning point, replacing bulky vessels with flexible bags and plate-based freezing platforms.

Unlike traditional air-cooled methods that risk cryoconcentration and inconsistent stability, direct-contact plate freezing allows for rapid, controlled cooling to $-80^\circ\text{C}$ in under ten hours. This evolution ensures superior product viability and scalability, providing a closed, automated path from filling to shipping. Explore how these advancements are redefining the standards for cold chain efficiency and sterility.