Establishing A Working Range For Effective MSC-EV Dose

By Stephen Lenzini

The growing number of clinical trials demonstrates the exciting therapeutic promise of MSC-EVs. However, the dose of MSC-EVs applied to patients across these studies has varied considerably in terms of the method of MSC-EV quantification and the amount of applied MSC-EVs. Being novel therapeutic candidates, given their heterogeneity and often limited in vivo retention, MSC-EVs challenge the conventional dose regimen framework. Consensus MSC-EV dose definitions are still in development across scientific and medical fields. In this blog, we explore the current state of MSC-EV dosing in completed and ongoing clinical trials, discuss the factors that affect MSC-EV dose, including MSC-EV quantification methods, and establish a target ‘working range’ for MSC-EV dose in humans.