Enabling MSC Harvest, Wash, And Concentration With UFMini®

Mesenchymal stem cells (MSCs) are vital to cell therapy for their immunomodulatory properties and scalability. As MSC-based therapies move toward commercial manufacturing, achieving high cell recovery and maintaining cell health during processing are crucial for clinical and economic success. Conventional cell separation methods often fall short, leading to low recovery and high viability loss from factors like excessive shear stress and inefficient separation.

A cell therapy developer evaluated the UFMini Single-Use Tubular Bowl Centrifuge as a closed, automated, and scalable solution for MSC harvest, wash, and concentration. The UFMini consistently delivered greater than 90% cell recovery and less than 5% cell viability loss, significantly outperforming the incumbent process's typical 60% recovery and meeting all defined performance targets. The low-shear design allowed for reproducible outcomes, processing 4-liter batches in under 30 minutes, and the system is modeled for scalability up to 80 L.

Learn how adopting a closed, low-shear system like the UFMini can streamline your transition from development to commercial-scale MSC manufacturing by accessing the full case study.