DynaChrom Single-Use Chromatography System Scaling Cation Exchange And Protein A Affinity Chromatography Operations

Scaling downstream purification requires consistent chromatography performance across column formats, from process development through manufacturing. Explore how the Thermo Scientific™ DynaChrom™ Single-Use Chromatography System supports predictable scale translation for monoclonal antibody purification using Protein A capture and cation exchange polishing. Testing across columns ranging from 5 mL to 15 L evaluates whether yield, chromatographic performance, and critical product quality attributes remain consistent as processes scale. Results demonstrate how maintaining residence time, linear velocity, and gradient formation can enable reliable transfer between development and production.

See how broad operating flow ranges, configurable single-use fluid transfer assemblies, and automated recipe control can help reduce scale-up risk and support efficient progression toward clinical and commercial manufacturing.