DynaChrom Single-Use Chromatography System: Integrated AEX And SPTFF Processing Using A Single Automated Workflow

Increasing bioreactor titers and molecular complexity are expanding process pools and straining downstream capacity. Integrating operations that are typically performed separately can reduce equipment needs, process transitions, and intermediate handling. A manufacturing-scale workflow combined anion exchange flow-through chromatography with inline single-pass tangential flow filtration on the Thermo Scientific™ DynaChrom™ Single-Use Chromatography System. Using TruChrom™ Bioprocess Control Software, the process coordinated chromatography flowthrough, buffer delivery, inline concentration, automated back-pressure control, product collection, and chase phases through one recipe. The integrated configuration maintained AEX flowthrough performance while concentrating the product stream for subsequent downstream processing.

Learn how unified hardware, single-use flow paths, inline sensing, and recipe-driven automation can simplify polishing and concentration at manufacturing scale.