Drug Substance Management With Single Use vs. Stainless Steel

Many companies in Biopharma face challenges in the transport of liquid drug substances from the drug substance site, after Downstream process, to the drug product site, before Fill & Finish.

There are many obstacles to overcome in order to preserve the highest possible quality and minimize product damage during this process. However, in order to choose the right technology, also financial aspects play a decisive role.

Partnering with a biopharmaceutical company with Single Use Support GmbH two different freeze and thaw technologies are being evaluated through the following aspects, such as financial (Total cost of ownership), quality and delivery time. The company is currently using stainless-steel technology and wanted to have a deeper look into the single use technology before they will increase their volume of bulk drug substance (BDS) to be transported. The aim of this case study was to compare the freezing/thawing process of BDS between both technologies, single-use and stainless steel.