Downstream Protein Purification

Bio-therapeutic manufacturing requires precise control of process parameters throughout production to ensure high yield and high quality products that are safe for patient use. The pressure on manufacturing facilities to increase yields, decrease turnaround time and reduce cost has never been greater than it is today, and presents a challenge that users must deal with on a day-to-day basis.

The purpose of this technical note is to present the benefits of the Thermo Scientific™ DHX™ Heat Exchanger and its applications:

• Downstream protein purification equipment configuration
• Benefits of using the DHX in harvest clarification, chromatography, ultrafiltration/diafiltration, viral filtration and bulk drug substance
• Heating/cooling efficiencies in a single pass