Newsletter | May 19, 2025

05.19.25 -- Do We Really Understand Plasmid Quality's Effects On mRNA Production?

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Future-Proof Your Process

Mobius® iFlex Bioreactors for upstream processes are a scalable portfolio of stirred tank bioreactors that leverage single-use bags with enhanced strength, made with our innovative Ultimus® film. Perfusion applications are supported with ease by integrating a perfusion tower, that uses the Cellicon® Filter Assemblies to retain cells in the bioreactor vessel while removing spent media. Future-proof your process with modular flexibility, and request a demo or technical consultation with our experts today!

FOCUS ON UPSTREAM MANUFACTURING

Do We Really Understand Plasmid Quality's Effects On mRNA Production?

Two experts examine the current guidelines and specs for plasmid DNA and question whether our understanding is sufficient.

Centrifuges Transforming Biopharmaceutical Development, Manufacturing

Emerging modalities and biotherapeutics require innovative production methods and technologies to support production at scale. Single-use centrifuges have the potential to become the new standard.

Unlocking The Potential Of Gamma Delta T Cell-Based Therapies

Gamma delta T cells are well suited for a variety of treatments due to their reduced risk of graft-versus-host disease. Learn more about two unique methods for clinical scale expansion of gamma delta T cells.

Upscaling hMSC Production Enhances EV Secretion, Cargo Profile

Explore how the dynamic microenvironment of bioreactors influences the production and composition of extracellular vesicles (EVs) secreted by human mesenchymal stromal cells (hMSCs).

Using A Closed System For High-Density Cell Culture

Find out how to enhance your projects and support high-density cell cultures using a closed system or closed loop system to minimize contamination and improve safety.

Host Cell Protein Analysis: Immunoassays

Learn about host cell proteins (HCPs) and the sensitive and specific orthogonal methods necessary to identify individual HCP impurities that persist through DS purification processes.

Amino Acid Analysis Indicates Metabolic Differences In MCB CAR T-Cells

Exploring the metabolic differences in CAR T-cells activated with multi-cytokine backpacks (MCBs) reveals correlations between CAR T-cell activation, nutrient metabolism, and efficacy.

Understanding UV Decontamination In Incubator Shakers

UV decontamination in incubator shakers offers a cost-effective, efficient solution for maintaining a sterile environment and mitigating contamination risks in bioprocess laboratories.

Scaling Up Viral Vector Harvest With Ease And Regulatory Compliance

Explore how scalable, high-performance solutions can help you overcome the challenges of large-volume viral vector production and accelerate the delivery of life-changing gene therapies.

Challenges And Solutions For Viral Product Development, Manufacturing

To execute complex viral product manufacturing, a service provider needs expertise in adherent cell culture capabilities, cell line productivity, and the intricacies associated with these products.

An AAV Platform Advancing Successful Viral Vector Based Therapeutics

Learn more about addressing substantial challenges in viral vector manufacture and an approach that drives rapid and predictable progression of high-quality viral vector products.

Media And Buffer Mixing Using The Xcellerex Magnetic Mixer

A common requirement for media and buffer preparation in biopharma processing is powder-liquid mixing. Review the performance of a 3000 L single-use mixing system for preparing aqueous solutions.

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Webinar: Maximizing Media Strategies: Insights on Boosting Performance

Join our live virtual roundtable on biopharmaceutical production! We'll discuss media formats, taming variability, and analytics for performance optimization. Experts will cover topics like bioprocess development, actionable analytics, and using quality attributes for scale-up decisions. Submit your questions anonymously in advance or during the event. Don’t miss out—register today! Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

A Disruptive Technology Accelerating Drug Development - Cytiva

Used Biopharma Bioreactors - Federal Equipment Company

XCell® ATF System: Breaking Productivity Barriers In Upstream Bioprocessing - Repligen

SUREtechnology Platform - KBI Biopharma

Scale AAV Production With VirusGEN Transfection Complex Stabilizer - Mirus Bio

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Webinar: Peptones and Vaccines: A Synergistic Approach to Enhanced Production and Efficiency

Discover how peptones can enhance vaccine production efficiency in this Thermo Fisher Scientific webinar. Learn how these versatile, cost-effective supplements support cell growth, viral production, and overall performance while reducing costs. Explore real-world data showcasing productivity gains and gain strategies for integrating peptones into your vaccine workflow to streamline development and accelerate market readiness. Click here to learn more.

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Webinar: Accelerate and Enhance Biomanufacturing Operator Training

Join Cytiva’s webinar to explore how a blended training approach—combining virtual reality, interactive eLearning, and onsite instructor-led sessions—can enhance operator performance and engagement. Learn how this strategy reduces human error, minimizes batch failures, and lessens dependence on internal experts. Discover how flexible, progressive training plans support continuous learning and help upskill both new hires and experienced staff in biomanufacturing environments. Click here to learn more.

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