Webinar | September 28, 2022

Development Of Effective Purification Processes For Bispecifics Using Affinity Capture And Mix-Mode Polishing Chromatography

KBI Biopharma and JSR Life Sciences have developed processes for the purification of BsAbs utilizing Amsphere A3 affinity chromatography followed by two polishing steps to eliminate undesirable homodimers and other impurities. Amsphere A3’s superior binding capacity, resin lifetime, and caustic stability can provide a cost effective, supply-chain stable purification strategy when paired with well-designed polishing steps. In addition to A3 affinity capture, KBI’s platform BsAb purification process includes mixed-mode anion exchange and cation exchange to eliminate homodimeric impurities. Together, KBI’s platform purification strategies present a powerful purification development method for many BsAb products.

In this webinar, we will review the following items for Bispecifics purification:

  • Challenges of Bispecifics purification
  • Protein A affinity capture chromatography design
  • Compare Protein A resin and alternative affinity capture resin for Bispecifics
  • Mixed-mode Chromatography design for Bispecifics
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