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As GLP-1 therapeutics continue to evolve, analytical scientists require robust workflows that can confidently characterize complex peptide structures, detect low-level impurities, and accelerate development timelines. Explore our latest application notes highlighting innovative LC and LC-MS technologies designed to overcome today's most challenging GLP-1 analytical workflows.
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Rapidly confirm intact masses and screen for impurities with confidence using Multi-Reflecting TOF technology combined with Intact Mass 1.9 software. This workflow enables high-throughput analysis while delivering the mass accuracy and resolution needed for efficient characterization of GLP-1 analogues.
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Characterizing isomeric amino acid substitutions remains a significant analytical challenge for peptide therapeutics. Learn how the Cyclic IMS P20 Mass Spectrometer provides enhanced separation and identification of site-specific isomeric amino acids in GLP-1 receptor agonists, improving confidence in structural characterization.
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Selecting the right stationary phase can significantly impact impurity resolution. This study compares BioResolve Peptide Phenyl-Hexyl and C18 Columns for separating GLP-1 receptor agonists from structurally similar impurities, providing guidance for optimizing peptide separations and improving analytical performance.
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Low-level impurities can be difficult to resolve using conventional chromatographic approaches. Discover how a Charged Surface 2.3 µm superficially porous Phenyl-Hexyl column enhances reversed-phase LC-MS analysis, delivering improved separation and detection of low-abundance impurities in GLP-1 therapeutics.
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