Demonstrating Bioprocess Scalability Through Platform Consistency

One of the central challenges in bioprocess development is ensuring that what works at bench scale will hold up as volumes increase by orders of magnitude. This application note examines how platform consistency — shared materials, impeller geometry, sparger design, and control architecture — can serve as a foundation for predictable scale-up, rather than relying solely on empirical re-optimization at each new scale.

Using constant power input per volume (~20 W/m³) as a primary scaling anchor, cultures run across 5 L, 50 L, and 5,000 L DynaDrive™ Single-Use Bioreactors produced closely aligned viable cell density, viability, and IgG titer profiles. The findings offer a practical look at how scaling criteria interact with reactor design, and what "straightforward scalability" can realistically look like in a production setting.

Download the application note for a walkthrough of the methods, control parameters, and results.