Controlling Aggregates In mAb Downstream Process Development

Aggregation remains one of the most persistent challenges in the downstream processing of monoclonal antibodies and antibody variants, impacting both product quality and overall yield. Left unmanaged, aggregates can complicate purification, reduce process robustness, and increase the risk of late-stage failures. This on‑demand webinar focuses on practical, process‑level strategies to control aggregation where it most often arises. You’ll gain insight into capture approaches that minimize aggregate formation early, polishing techniques designed to effectively separate and remove aggregates, and ways to fine‑tune concentration and diafiltration conditions to better handle high‑concentration mAbs. The discussion emphasizes real-world considerations across chromatography and tangential flow filtration, helping teams make informed decisions without over‑engineering their processes.

Watch to gain actionable guidance you can apply directly to development and scale‑up efforts.