Chromatography Polishing Under Pressure: New Demands

By Henrik Ihre, Ph.D., Distinguished Fellow at Cytiva

Platform monoclonal antibody processes were designed for a different era. As upstream titers climb and the range of antibody formats expands, the assumptions embedded in conventional polishing strategies are under pressure. Impurity profiles are more complex, structural diversity is greater, and the margin for error in process design is narrowing.

In a panel discussion, Cytiva scientists Eva Heldin, Niklas Jungnelius, and Jakob Liderfelt examine what this shift means for chromatography polishing specifically: why it is becoming a more consequential point of differentiation in process design, how productivity and process economy factor into polishing decisions, and where current approaches may fall short.

Access the full article for a closer look at how downstream processing is adapting to these demands.