Newsletter | June 25, 2025

06.25.25 -- Characterizing Product- And Process-Related Impurities In Multispecifics

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Webcast: New Mixed-Mode Media for Biotherapeutic Purification

This 15-minute on-demand webcast presents an analysis of high-throughput resin screening data for an IgG1 monoclonal antibody (mAb), an IgG4 mAb, and a bispecific antibody in downstream process development using Bio-Rad’s Nuvia wPrime 2A Media. The optimization process included adjusting the charge state of the resin. The resin provided a wide design space, resulting in increased yields with reduced aggregates and host cell proteins. Watch the webcast now.

FOCUS ON FILL-FINISH

Characterizing Product- And Process-Related Impurities In Multispecifics

By Bioprocess Online Live

In this segment from the Bioprocess Online Live event, “Challenges And Considerations For Purifying Multispecific Molecules,” our panelists examine the types of common impurities manufacturers encounter in multispecific purification and explain the differences between product-related impurities and process-related impurities.

Addressing Key Challenges Of High Concentration Formulation Development

Webinar | Lonza

High concentration formulations often present challenges with regard to viscosity as well as potential changes in the behavior upon stability. Discover solutions to mitigate high viscosity.

Freezing And Thawing Of Protein Solution

White Paper | Single Use Support

Parts of a protein solution will show less activity based on the stress it's exposed to during freezing and thawing. It's important to optimize the freezing and thawing process to minimize activity loss.

FILL-FINISH SOLUTIONS

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Aseptic Connectors: MicroCNX® Nano Series Datasheet - CPC

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Drug Product Fill And Finish - Curia

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Capacity Update April 2025: Fill/Finish - Argonaut Manufacturing Services

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Capacity Update April 2025: Fill/Finish - Bora Pharmaceuticals

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Explore the latest biotech equipment and solutions — all online, wherever you are.

Don't miss the next Bio-Expo Live! This interactive, multi-day event is organized by stages of drug development and production, making it easy to find sessions tailored to your company's needs. Browse the full agenda and register for free to join the conversations most relevant to your work.

FOCUS ON DOWNSTREAM MANUFACTURING

A Faster And More Economical Path To Investigational New Drug Applications

Article | By William C. Barrett, Ph.D. and Doug Puzia, W.L. Gore & Associates

Read how new membrane-based protein A affinity chromatography technology can greatly shorten the time it takes to get to IND while also making the process less expensive and more adaptable.

Primary Clarification Of CHO Cells With Single-Use Centrifuge Tech

Application Note | CARR Biosystems

Learn about a single-use cell harvesting system designed for primary clarification of mammalian cell cultures and harvesting along with how the system performs in a cell culture clarification process.

When Measuring Filter Performance, Is Performance Absolute?

Article | By Mark Ayles, Cytiva

See why high-performing filters are inadequate for critical filtration processes and why sterilizing-grade filters are necessary to effectively remove undesirable species, including bacteria and viruses.

Leveraging Efficiency From CLD To Clinical Manufacturing Of mAbs

White Paper | Curia

Discover how our efficient strategies can propel your mAb from discovery to clinical manufacturing in as little as 18 months.

DOWNSTREAM MANUFACTURING SOLUTIONS

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Perform Multiple Chromatography Steps On A Single System - Sartorius

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Praesto AP+80 Chromatography Resin - Ecolab, Purolite Resins

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