Article | January 13, 2022

Cell Culture Media Analysis For Gene Therapy

Source: 908 Devices
DNA Gene Strand

There are many opportunities to improve manufacturing efficiencies for both plasmid DNA and the viral vectors where the cell culture media used for the production cell lines is vitally linked to their productivity and is a critically important aspect of any manufacturing platform. In-depth characterization could aid in optimization efforts to decrease COGS and improve the productivity of host cell lines through better understanding of nutrient requirements or to facilitate process development efforts such as adapting adherent cells to suspension culture and more. Ideally, the media selected should provide the essential nutrients to facilitate high productivity, consistency and quality as well as being amenable to support scale up to larger manufacturing platforms.

At-line and frequent spent media analysis can enable a faster in-house process development pace since there is no need to wait for samples to be processed at a core lab or through outsourced contract services especially with the BSL2 safety requirements associated with viral vectors for transport and handling.

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