Bioprocess Sampling Case Study

Simplifying sampling with a closed system solution

Need

A vaccine manufacturer required a novel process sampling solution for taking multiple conical tube samples at varying time points. In order to provide the highest level of sterility assurance, samples would need to be taken in a closed manner without using a biological safety hood. Test methods required samples to be taken using multiple tube materials and at varying volumes.

Solution

Avantor designed, prototyped, and commercialized a GMPcompliant, customized single-use solution, an OmniTop Sample Tubes® Manifold, that achieved all the benchmark requirements. A proprietary 10-leg, platinum-cured, silicone-molded manifold was used as the spine of the system, directing fluid to each of the conical tube collection vessels.

Results

The OmniTop Sample Tubes® Manifold was integrated into the customer’s work stream and almost immediately, the customer saw an increase in process efficiency and sterility assurance. This platform sampling solution is capable of sampling at multiple points in their process and with the flexibility designed in to allow for a multitude of sampling options.