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| Overcoming Bispecific Antibody Purification Challenges | The purification of bispecific antibodies (bsAbs) can be challenging due to the aggregation and chromatographic approaches. Process chromatography scientists compared CHT Ceramic Hydroxyapatite Media to traditional cation exchange (CEX) resins for bsAb workflows. Over 97% purity, low levels of high molecular weight impurities (HMW), and an eightfold decrease chromatography-induced aggregation were achieved with CHT compared to CEX-based resins. View the full article. |
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FOCUS ON DOWNSTREAM MANUFACTURING |
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By Yadnyesh Patel, microbiology subject matter expert | The author continues his article series on bacterial endotoxin testing by discussing depyrogenation and calculating endotoxin limits and maximum valid dilution (MVD), including those for active substances and excipients, combination products, and medical devices. |
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| The Heroes Of Vaccine Development: Lipid Nanoparticles | White Paper | By Michael Nguyen, Ph.D., Helix Biotech | Lipid nanoparticles (LNPs) have played a crucial role in COVID-19 vaccine development as efficient mRNA delivery systems, exhibiting versatility and effectiveness in accelerating the process. |
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| Revolutionizing Particle Characterization With Image Analysis And ML | White Paper | By Amber Raines, Ph.D., Jonathan Rocher, Ph.D., and John F. Carpenter, Ph.D., KBI Biopharma | The biopharmaceutical industry is increasingly employing micro-flow imaging for particle characterization, owing to the superior insights it can afford into product quality and process controls. |
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| Achieving Protein A Purification Using DurA Cycle A50 | Application Note | Purolite, An Ecolab Company | This protein A resin, developed for purifying various mAbs, ensures consistent agarose beads with a uniform particle size distribution. Explore the resin's recommended conditions and parameters. |
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| AI and machine learning are the buzzwords of the decade, often accompanied by lofty promises — but what do they really mean for biopharma? How can these technologies be adopted to improve biomanufacturing processes, testing, and quality? Join Bioprocess Online Live for an exploration into the practical applications of AI/ML in biomanufacturing, its barriers to adoption, and how regulators can help standardize use across the industry. Registration is free thanks to the support of Atum Bio. |
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DOWNSTREAM MANUFACTURING SOLUTIONS |
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| Webinar: Novel Chromatography for Antibody Variants and Recombinant Proteins | Developing purification protocols for molecules like bispecific antibodies, antibody fragments, and recombinant proteins might pose challenges. Join Cytiva on September 5th as they discuss strategies for streamlining purification processes using MabSelect™ VH3 resin for bispecific antibodies and Cytiva™ Protein Select™ resin for recombinant proteins. Click here to learn more. |
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