Achieving Protein A Purification Using DurA Cycle A50

The DurA Cycle A50 is a protein A resin developed for the purification of various monoclonal antibodies (mAbs) and related constructs. It offers enhanced capacity, stability, and minimal protein A leakage. The resin, part of the Purolite bioprocessing resin family, is produced using patented Jetting technology, ensuring consistent agarose beads with a uniform particle size distribution. The DurA Cycle A50 binds to both the Fc and VH domains of antibodies, and Purolite provides a guide with recommended conditions and parameters for its use, as well as support for further optimization or troubleshooting. The development of the DurA Cycle A50 marks a significant advancement in mAb purification and chromatography processes.