Automated Glucose Feeding Based On Online Glucose And Lactate Measurements

The ability to adjust glucose feed rate benefits cell growth and viability, and automation of bioprocess controls can play a key roll in making this possible. Controlling glucose and lactate levels leads to more consistent drug substance quality and yield.

In this study the MAVEN, an online (samplefree) device, is leveraged for monitoring of glucose and lactate with automated glucose feed control. The MAVEN provides on-line automated analysis and data processing with in situ probe sampling. Using this defined control strategy enables more intensified and stable cell culture processes.