Newsletter | November 6, 2025

11.06.25 -- Antibody Purification: Tackling Complex Challenges

 

Discover The Future Of Antibody Purification

 

Discover how novel antibody formats are reshaping biologics — and the purification strategies that make them viable. In this white paper, Beyond Traditional Monoclonal Antibodies, Ecolab’s Purolite™ team explores the latest purification technologies tailored for next-generation antibody formats. Learn how novel affinity resins like Praesto™ 70 CH1 and Praesto Jetted A50 HipH are enabling scalable, high-yield production while minimizing aggregation and impurity risks.

 

Maximizing Yield And Purity With Praesto™ CH1 Resin

Discover how Ecolab’s partnership with Repligen delivered another important advancement in antibody purification — Praesto CH1 resin. This innovative resin is designed to revolutionize the purification of complex antibody-based therapeutics by binding with high affinity to the CH1 domain of human IgG molecules. Learn about the value of this resin for your applications, as well as the importance of removing contaminants during the capture step. Watch the video here.

 

Gain Efficiency And Flexibility With Chromatography Resins

The Praesto AP+ Platform, including the high-performance AP+50 resin, is designed to meet the demands of modern biopharmaceutical purification. Built around a proprietary engineered protein A ligand based on the C domain, these resins offer technical equivalence to legacy platforms ensuring seamless integration into existing workflows with minimal disruption.

 

Enable The Elution Of Fc-Containing Molecules At Higher pH Levels

With the current advancement of antibody engineering and drug development, new antibody types such as Fc-fusion proteins and other antibody-derived drugs are emerging. Analyze application data from the use of a new Protein A resin, which enables elution of Fc-containing molecules up to pH 5.0.

 

SOLUTIONS

Unlock The Full Potential Of Your Downstream Purification Processes With This Affinity Resin Selection Guide

This resource for Process Development professionals provides in-depth knowledge into the latest advancements in affinity chromatography resins. Access the guide to gain further insights into the ideal resins available for your intended molecule type and criteria. This includes the innovative resins that were designed to meet specific purification challenges for more complex molecules, that are increasingly relevant in today’s world.

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