Allegro™ Connect Virus Filtration System

Manual and semi-automated filtration often lacks robustness, increasing the risk of critical deviations, non-conformities and sometimes even batch loss. The process data that is generated by the current systems is often insufficient and hard to access, making it very difficult to accurately evaluate any deviations or conduct routine process analysis, causing a significant impact on both cost and labor.

Current trends show an increasing number of multi-product facilities being built and/or being retrofitted together with significant investments in automated bioprocessing equipment. Most of the existing automated virus filtration systems are designed to fit a specified process scale and are therefore less flexible.

The solution is a fully automated configurable system

The Allegro Connect Virus Filtration System is a fully automated and completely flexible platform that can accommodate a product stream from 200 L to 2000 L bioreactor scale. It is a single-use automated filtration system designed to deliver robust process control during this critical downstream step.

This next generation compact and elegant system is designed to minimize risk through a fully automated process with recipe-controlled steps, including pre-use manifold leak test, pre-use and post-use filter integrity tests (with the help of an integrated Palltronic® Flowstar IV Filter Integrity Test Instrument), system priming, product filtration and buffer chase, with all data stored in a batch reporting system, significantly reducing non-conformities and manual labor. New innovative design features enable manifolds to be configured to meet a variety of process needs; supporting a wide range of liquid filter capsules (prefilters and virus filters) and also accommodating non-Pall filters.