06.05.26 -- Aligning Upstream And Downstream Development (Part 2)

The ISABEL trap, which deploys interferometric scattering as a highly sensitive, fluorophore-label-free detection scheme, enables precise interpretation of the actions of complex biomolecular nanoparticles.

Paper-based records still shape many life sciences operations, but they bring hidden risks. Gain insight into how manual documentation impacts accuracy, efficiency, and compliance.

Explore a faster approach to vector copy number measurement that replaces DNA extraction with direct cell lysis and digital PCR, delivering accurate, reproducible results across fresh and frozen samples.

Discover how a systematic, data-driven developability workflow can accelerate biologic formulation development, identify risks earlier, and optimize stability and manufacturability.

Next Generation Manufacturing (NGM) integrates advanced process design, digital innovation, and strategic facility planning to facilitate agile, efficient, and sustainable biopharmaceutical production.

Traditional biomanufacturing relies too heavily on trial and error. By integrating AI and mechanistic models into early design, developers can overcome productivity limits and accelerate timelines.

Manual processes in CMC development create costly delays and compliance risks. Examine how digitization can eliminate bottlenecks, improve traceability, and accelerate timelines.

Read about how meticulous purification optimization can maximize recovery and impurity removal by leveraging scalable downstream technologies to meet regulatory and process economy requirements.

Delve into the complexities of scaling decisions to gain insights from developers and a CDMO. Learn about their mutual interest in achieving successful scale-up and strategies for avoiding common pitfalls.

Find out how sanitary clamps provide uniform 360° compression. Distributing even pressure by triangulating pressure points, these clamps ensure consistent sealing.

Mastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production.

Persistent disruption is redefining biopharma supply chains. See how regional manufacturing, integrated risk management, and closer collaboration help build resilience and improve agility.

Laboratory refrigerators and freezers are essential for preserving research integrity. Uncover six key factors to consider when choosing cold storage solutions to protect your samples.

Although polymer bags are an excellent choice for cold chain use, not all polymer films perform the same way, even if their specifications rate them for use at low temperatures.