ÄKTA ready™ Chromatography System XL

The ÄKTA ready™ chromatography system XL is a liquid chromatography system designed with a wide operating range to cover the manufacturing capacity needed from clinical to commercial scale. To meet the capacity demands from single-use upstream processes (2000 L high-titer feeds), the system operates large-scale columns (up to 1200 mm), using two flow kit sizes that cover a broad range of flow rates from 45 to 3500 L/h.

The single-use flow path minimizes the need for cleaning and cleaning validation, allowing for quick changeover between production runs, while eliminating the risk of carryover. The system offers the accuracy and documentation required for use in a GMP-regulated environment.

Key features include:

• Rockwell PLC and Ethernet/IP for robust communication to automation platforms
• Interactive process picture in UNICORN™ software for control and monitoring
• Connect to up to five Xcellerex™ XDUO mixers to integrate control and monitoring of fluid management with the purification process.

UNICORN™ software provides intuitive and flexible method creation, system control, and process evaluation to simplify your purification workflows. Connecting flow kits is quick and easy and can be confirmed by an installation test within the software.

For users who require chromatography equipment to be used on their facility’s plant-wide automation platform, ÄKTA ready™ systems can be customized with a distributed control system or can connect to automation options via Open Platform Communications-Unified Architecture (OPC-UA).

ÄKTA ready chromatography system XL is part of the single-use chromatography system family from Cytiva, which are designed to work seamlessly with ReadyToProcess™ prepacked columns.