12.22.25 -- Addressing The Consistency Challenge In Cell Therapy With iMSCs

Discover how diagnosing ribosome pausing sites and optimizing codon usage dramatically improves bispecific antibody titers, turning difficult-to-express candidates into viable therapeutics.

Learn about the effectiveness of a xeno-free serum replacement in mesenchymal stem cell (MSC) culture and its potential to enhance cell growth and reduce variability compared to fetal bovine serum.

Optimizing pDNA production in E. coli requires strategic media selection and scale-up planning. Explore a study that identifies ideal conditions for high-yield manufacturing.

EV production must align with CMC and regulatory standards before it can reach its full potential. This study compares conditioned medium across scalable platforms to optimize EV manufacturing.

Gain a foundational understanding of the process for culturing mesenchymal stem cells in stirred-tank bioreactors and learn about the key parameters for successful scale-up.

Learn about a high-throughput screening method that successfully optimized cell culture media, leading to a greater than 3-fold improvement in viral genome titer for AAV2 production.

The top five common cell line development pitfalls — scalability, stability, complexity, analytics, and tech transfer — can be avoided with experienced partners and integrated, predictive strategies.

Advancements in high-sensitivity residual DNA testing enhance the precision of plasmid DNA purity analysis, ensuring compliance with regulatory standards critical for manufacturing processes.

Unlock superior non-viral CAR T manufacturing outcomes by combining gentle microbubble T cell isolation with electroporation. See how this approach boosts cell viability and transfection efficiency.

Learn about a next-generation transfection system that requires 50% less plasmid, decreases transfection reagent consumption, and yields higher AAV productivity to reduce cost per dose.

Glycoprotein therapies face variable glycan profiles. An alternative approach, IVGE, moves modification outside the cell for true molecular control, ensuring consistency and speed.

A new functionally-closed cell expansion system featuring a hollow-fiber membrane and customizable protocols is streamlining the production of stem cells for regenerative medicine.