Application Note

Adapting Single-Use Chromatography To Manufacturing Scale

Source: Cytiva
GettyImages-1462154865 Scientist Using Laptop In Manufacturing Facility

Single-use technologies provide the flexibility required to meet the needs of multiproduct facilities. They require a lower capital investment and save time significantly by eliminating cleaning and cleaning validation procedures. Although these technologies are widely adopted in upstream production processes, what is necessary to transition them to downstream manufacturing scale? This article explores strategies for accommodating the ever-increasing upstream titers and volumes to prevent downstream purification from becoming a bottleneck. Learn about transitioning single-use chromatography to manufacturing scale, addressing single-use column scalability challenges, aligning with the needs of upstream titers to achieve optimal process economy, single-use chromatography systems with enhanced flow rates, and the importance of ease of use.

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