03.11.26 -- A Practical Look At Modern Downstream Processing For Biologics

There are two primary filling methods for pre-filled syringes. Explore the pros and cons of each approach, highlighting why barrel filling is generally preferred in the pharmaceutical industry.

Examine strategies to maximize drug product recovery during sterile filtration, minimize hold-up volume, and reduce dilution after PUPSIT to ensure higher yield, improved efficiency, and less waste.

This protein capture device demonstration showcases a cycling protocol that uses fast loading and non-loading residence times as well as a rapid CIP out to 100 cycles.

In vitro glycoengineering enables precise control of therapeutic protein glycosylation, streamlining product consistency and development through a phased, risk-managed integration after initial purification.

Chromatography resins are aiding in the delivery of cancer and inflammatory disease therapies. Learn how ion exchange resins act as therapeutic carriers for advanced drug delivery.

The biopharmaceutical industry faces growing downstream processing challenges in purifying complex biologics efficiently and at scale.

Discover how novel affinity resins address purification challenges for complex antibodies, such as bispecifics and fragments, by preventing aggregation and targeting alternative binding domains.

For sensitive biologics and viral vectors, risk extends beyond simple contamination. Utilizing inert barrier films on contact surfaces reduces compound migration and adsorption, maintaining dosage accuracy.

Observe two experimental methods for determining choked flow: the minimum controllable pressure method and the choke point method.