Newsletter | May 29, 2024

05.29.24 -- 7 Bioprocess Intensification Strategies

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Designing a Plasmid DNA Downstream Purification Process

Discover in our technical article the Downstream Purification in the Plasmid DNA (pDNA) Manufacturing Process. Plasmid DNA (pDNA) is an essential component of, and key technology for production of viral vector, mRNA, and vaccine therapies. The far-reaching potential of novel therapeutic modalities and vaccines that rely on pDNA is driving increased demand and the need for improved production strategies – Read Now!

FOCUS ON DOWNSTREAM MANUFACTURING

7 Bioprocess Intensification Strategies

“Process intensification” is one of those big umbrella terms that unfairly implies a concept that comes with an instruction manual. It doesn’t. It isn’t prescriptive. It doesn’t have to start in a specific place, and it really never ends.

Use Single-Use Connectors To Increase The Integrity Of Closed Systems

While single-use connectors can reduce many of the risks associated with tube welding, it is essential the ones you select meet the sterility and reliability needs of your application.

Identify And Quantify AAV Fill States Using Analytical Ultracentrifugation

Explore how to implement analysis for AAV preparation using sedimentation velocity analytical ultracentrifugation and multiple detection wavelengths to identify various fill states in AAV preparation.

Achieving Optimal Purity And Recovery Of Monoclonal Antibodies

Customize the polishing steps of your mAb to achieve optimal purity and recovery. Learn about two resins that can be used in chromatography and purification processes to optimize your mAb yields.

Top Challenges In Recombinant Protein Purification Process Development

Get insights from process developers working with recombinant proteins that cannot be purified with affinity chromatography.

Evaluate Large-Scale Monolithic Columns For AAV Capsid Separation

Review the evaluation of highly reproducible QA-modified CIM® monolithic columns. The aim was to elute AAV capsids in a very narrow conductivity range, regardless of the batch and column size.

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Webinar: How to value automation with the Return on Invested Capital model

Join us on June 4th when we’ll discuss the ROIC Capital of an automated facility for a Biophorum Digital Plant Maturity Model level of 2.0, 2.5 and 3.0. We will break down assumptions for developing the model, applications, inputs, COGS, and outputs of the model and share how ROIC correlates with the overall digital maturity of your operation. Click to learn more.

DOWNSTREAM MANUFACTURING SOLUTIONS

Fill And Finish - JOINN Biologics

High Binding Capacity And Short Residence Time For Antibody Purification - W.L. Gore & Associates

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