Newsletter | April 21, 2025

04.21.25 -- 4 Key Solid Tumor Therapy Objectives iPSCs Can Help Achieve

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Webinar: From Cell Line Development to Upstream Optimization: Enhancing Biologics Quality and Productivity

Join Samsung as they share how to enhance purity, stability, overall performance and further increase productivity by 2-fold while maintaining quality. In addition, learn how the S-AfuCHO™ cell line, developed from its proprietary S-CHOice® host cell, produces fucose-free antibodies with significantly enhanced ADCC activity, leading to more potent therapeutic effects. Click here to learn more.

FOCUS ON UPSTREAM MANUFACTURING

4 Key Solid Tumor Therapy Objectives iPSCs Can Help Achieve

Induced pluripotent stem cells offer some key biologic, technical, and financial advantages over more established PBMC-derived therapies.

Simpler, Faster, Cheaper Advanced Therapy Manufacturing

Discover how TFDF-based perfusion technology boosts lentiviral vector production by over 10-fold, slashes costs, and accelerates the commercialization of CAR-T and other advanced cell therapies.

Boosting Cell Culture Yields With Intensified Fed Batch Processing

Traditional fed-batch cell culture processes face limitations due to inherent cell line restrictions and accumulation of byproducts, necessitating new approaches that improve cell performance.

Dynamic Trends Shaping The Future Of Microbial Fermentation

Drug developers must understand the latest trends in microbial fermentation. By leveraging innovative methods and technologies, developers can unlock new opportunities and improve patient outcomes.

Real-Time Monitoring Of Key Bioprocess Parameters

The success of this experiment shows how the integration of Process Analytical Technology probes into bioreactors can enhance process understanding and enable precise bioprocess monitoring and control.

Leveraging Transposase Technologies To Optimize Cell Line Development

Enable a wide array of genomic manipulation with the more regulated and efficient genomic insertion that's made possible by transposase-based technologies.

Bioprocess Scale-Up: From Classrooms To Pilot Production

In this article, the author, an Associate Professor at Universiti Sains Malaysia, shares their positive experience using two specialized benchtop bioreactors to enhance bioprocess education and research.

Enabling Commercial AAV Manufacturing By AAV Stable Producer Cell Lines

A high-performance, helper virus-free stable producer cell line is derived from proprietary high-producer HEK293 cells and is cultivated in a chemically defined, serum-free, ADCF medium in suspension.

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Multispecific molecules bring added complexity to downstream purification—think incorrect chain pairings, aggregation, fragmentation, and lower yields. Join Bioprocess Online Live as we explore how developers are addressing these challenges to achieve high purity and efficient processes. Gain insights into key considerations for downstream teams when designing purification strategies for these advanced biologics. Registration is free thanks to the support of Thermo Fisher Scientific.

UPSTREAM MANUFACTURING SOLUTIONS

Quantum Flex Cell Expansion System - Terumo BCT

Stainless Steel Centrifuges For Advanced Therapy Manufacturing - CARR Biosystems

A Complete Portfolio Of Cell Lines Designed For AAV Production - Cytiva

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Webinar: Sustainable Manufacturing Through Efficient BioProduction Unit Operations

Join our webinar to explore sustainable bioprocessing solutions, tackling plastic waste with biobased consumables, process intensification, and optimized operations. Learn how seed train intensification, high-density cell banking, and efficient bioreactor scaling can reduce the environmental footprint. Gain insights from experts on implementing greener, more efficient workflows in biomanufacturing for a sustainable future. Click here to learn more.

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