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FOCUS ON UPSTREAM MANUFACTURING |
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By Shubhranshu Gupta, Ph.D., cell therapy expert | Induced pluripotent stem cells offer some key biologic, technical, and financial advantages over more established PBMC-derived therapies. | |
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| Simpler, Faster, Cheaper Advanced Therapy Manufacturing | Application Note | Repligen | Discover how TFDF-based perfusion technology boosts lentiviral vector production by over 10-fold, slashes costs, and accelerates the commercialization of CAR-T and other advanced cell therapies. |
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| Boosting Cell Culture Yields With Intensified Fed Batch Processing | Application Note | By Dongyoung Park, Minyong Eom, Hakyung Kim, and Jaewook Baek, Samsung Biologics | Traditional fed-batch cell culture processes face limitations due to inherent cell line restrictions and accumulation of byproducts, necessitating new approaches that improve cell performance. |
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| Real-Time Monitoring Of Key Bioprocess Parameters | Application Note | 908 Devices | The success of this experiment shows how the integration of Process Analytical Technology probes into bioreactors can enhance process understanding and enable precise bioprocess monitoring and control. |
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| Bioprocess Scale-Up: From Classrooms To Pilot Production | Article | An interview style article, authored by Joo Shun TAN (陈裕声), Universiti Sains Malaysia (USM), INFORS HT | In this article, the author, an Associate Professor at Universiti Sains Malaysia, shares their positive experience using two specialized benchtop bioreactors to enhance bioprocess education and research. |
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| Enabling Commercial AAV Manufacturing By AAV Stable Producer Cell Lines | Poster | By Gang Li, Chien-Ting Li, Khanh Ho, Friedrich Michael Haller, Leila Aneke, et al., Lonza | A high-performance, helper virus-free stable producer cell line is derived from proprietary high-producer HEK293 cells and is cultivated in a chemically defined, serum-free, ADCF medium in suspension. |
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| Multispecific molecules bring added complexity to downstream purification—think incorrect chain pairings, aggregation, fragmentation, and lower yields. Join Bioprocess Online Live as we explore how developers are addressing these challenges to achieve high purity and efficient processes. Gain insights into key considerations for downstream teams when designing purification strategies for these advanced biologics. Registration is free thanks to the support of Thermo Fisher Scientific. |
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UPSTREAM MANUFACTURING SOLUTIONS |
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| Webinar: Sustainable Manufacturing Through Efficient BioProduction Unit Operations | Join our webinar to explore sustainable bioprocessing solutions, tackling plastic waste with biobased consumables, process intensification, and optimized operations. Learn how seed train intensification, high-density cell banking, and efficient bioreactor scaling can reduce the environmental footprint. Gain insights from experts on implementing greener, more efficient workflows in biomanufacturing for a sustainable future. Click here to learn more. |
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